The Malaria in Pregnancy (MiP) Library is a regularly updated, comprehensive bibliographic database of published and unpublished literature relating to malaria in pregnancy, including a trial registry of planned and ongoing trials. The MiP library is a product of the Malaria in Pregnancy Consortium and is available free of charge.
For more information on the MiP Library and inclusion criteria click the “About” Tab.
Article highlights from the update in May 2014:
In May 2014, over 120 new entries were added to the MiP library. New entries include peer reviewed journal articles, PhD and MSc theses, and reports. Here we highlight a few articles that may be of particular interest:
In the previous update, the use of daily cotrimoxazole for malaria prevention among HIV-infected women was highlighted. In this update, Manyando et al report the results of a trial in Zambia comparing daily cotrimoxazole vs. IPTp with SP for the prevention of malaria among 346 HIV-infected (n=52) and uninfected pregnant women with similar pregnancy outcomes reported by treatment arm. HIV-infection is associated with an increased risk of malaria, and with the widescale use of antiretroviral drugs it is important to ascertain whether there are interactions between antimalarials and antiretrovirals that have clinical significance. Kayentao et al report on the pharmacokinetics of quinine in the presence of nevirapine based anti-retroviral therapy, confirming there may be reason for concern, and a need for further research.
The wide penetration of mobile phones in rural areas has opened up avenues to improve health care. A cluster randomized trial in Zanzibar by Lund et al reports on how the use of mobile phone messages and vouches can improve (timely) antenatal attendance; the uptake of IPTp, a secondary outcome, increased although this was similar in both arms (65% vs. 52% for IPTp2 in intervention and control arm respectively), and not statistically significant.
New technology is also used to examine malaria at the placenta level. VAR2CSA is a Plasmodium falciparum protein expressed on erythrocytes, and chondroitin sulfate A (CSA) is a receptor present on syncytiotrophoblasts, the placental layer that divides the maternal and foetal circulation. Ditlev et al introduce nanotechnology to examine antibody fragments important for maternal immunity to placental malaria. Bordbar et al examined patterns of sequence variation of a segment in VAR2CSA in a large collection of P. falciparum field isolates from different malaria-endemic areas, including Africa, Asia (Cambodia), Oceania (Papua New Guinea), and Latin America (Peru).
Several articles report on malaria in pregnancy and immunity in areas where malaria transmission is less intense, such as Asia and South America. Meastre & Carmona-Fonseca present a review of immunity in these areas, and Agudela et al present findings of a study of cellular responses to malaria in pregnancy in Colombia. Gnidehou et al report a puzzling finding of antibodies to VAR2CSA among men and children with malaria (P. falciparum and P. vivax) in Colombia, whereas in studies in Africa these have mainly been observed in multigravidae.
For readers who would like information on the interactions between malaria and iron in pregnant women, a review by Sangare et al summarizes the evidence to date.
Please note that we are in the progress of revising the layout and functionality of the malaria in pregnancy library, and this has delayed provision of the April 2014 update. Any feedback on the new functionality would be appreciated, in particular from geographic locations with limited internet access.